Transcription factors have long been considered undruggable despite their central role in disease. New therapeutic modalities are finally changing that equation, bringing fresh hope to targeting these master regulators of gene expression.
Groundbreaking research suggests our understanding of how genetic building blocks formed may need significant revision. Scientists have discovered evidence that challenges the established sequence of amino acid emergence, with implications for searching life on other worlds.
Scientists are proposing a fundamental shift in our understanding of how life’s genetic machinery first emerged, according to new research published in the Proceedings of the National Academy of Sciences. The study, led by University of Arizona researchers Joanna Masel and Sawsan Wehbi, suggests that current models of amino acid development may reflect biases in how we distinguish between living and non-living chemical processes.
Researchers have developed an artificial intelligence approach that could revolutionize pharmaceutical discovery. The method reportedly identifies relevant compounds up to 17 times more effectively than traditional screening techniques.
An artificial intelligence system trained on extensive cellular data could significantly accelerate the development of new medications, according to research published in Science. The approach builds on growing trends in pharmaceutical research where AI technologies are being deployed to streamline the traditionally labor-intensive process of drug discovery.
Scientists have uncovered a surprising dual function for a key fat-metabolizing enzyme that operates both as a fat-breaker and gene regulator. This discovery helps explain why people with mutations in this enzyme develop lipodystrophy rather than obesity and could lead to new therapeutic strategies for metabolic disorders.
Scientists have discovered that a well-known fat-digesting enzyme plays a surprising second role as a genetic regulator within fat cells, according to a new study published in Cell Metabolism. The research reveals that hormone-sensitive lipase (HSL), previously understood only as an enzyme that breaks down stored fat, also enters cell nuclei to control gene activity that maintains healthy fat tissue structure.
The Two-Faced Nature of Our Genetic Inheritance In the intricate landscape of human genetics, researchers are uncovering surprising dualities that…
The False Dichotomy in Biomedical Research In the polarized landscape of modern biomedical research, a simplistic narrative has taken hold:…
