Brain Cell Clocks Rewired by Alzheimer’s Pathology, Study Reveals
Scientists have discovered that amyloid pathology fundamentally reprograms daily biological rhythms in brain cells. The findings reveal how Alzheimer’s disease disrupts cellular timing while preserving core clock mechanisms.
Circadian Disruption in Brain Cells
Groundbreaking research published in Nature Neuroscience has revealed how amyloid pathology associated with Alzheimer’s disease reprograms daily biological rhythms in crucial brain support cells. According to the report, while core circadian clock genes remain robust, amyloid plaques trigger widespread changes in how hundreds of genes cycle throughout the day in astrocytes and microglia.